The laboratory canine

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Title:

Personal Author:

Field, Garrett

Series:

The laboratory animal pocket reference series

Publication Information:

Boca Raton, F.L. : CRC/Taylor & Francis, c2007

Physical Description:

159 p. : ill. ; 24 cm.

ISBN:

9780849328930

Subject Term:

Dogs as laboratory animals

Added Author:

Jackson, Todd A.

Available:*

Library	Item Barcode	Call Number	Material Type	Item Category 1	Status
Searching... PSZ JB	30000010273903	SF407.D6 F54 2007	Open Access Book	Book	Searching... Unknown

Laboratory animals, including dogs, play an important role in biomedical research and medical advances. Dogs have a long history of use in research and have contributed enormously to the health and welfare of both humans and animals. The humane care and management of these animals is a fundamental component of their use in medical research.

The Laboratory Canine clearly presents basic background information covering subjects that apply specifically to dogs used in research settings, such as basic biological features, husbandry, management, veterinary care, experimental methodology, and resources. The book offers guidance on performing a detailed physical examination, including necessary veterinary supplies, clinical signs of illness, clinical conditions, and reference tables of widely used veterinary drugs. It discusses the human-animal bond or the relationship between people and animals and its significance and importance to the quality of research, the health of the animals, and the emotional health of staff caring for or working with animals. It also examines anesthetic and surgical procedures that include pre-, intra-, and post-anesthesia/operative monitoring. The Laboratory Canine contains reference charts for monitoring patients through post-operative recovery and reference tables for anesthetics and analgesics.

Because dogs are a highly visible species in the eyes of the public and regulators, it is important that individuals working with laboratory canines have the proper training and experience. This valuable resource is ideal for those charged with the care and use of canines in a research setting.

1 Important Biological Features	p. 1
Origin of the Dog	p. 1
Dog Breeds	p. 3
Dog Behavior	p. 4
Anatomic and Physiologic Features of Dogs	p. 6
Normative Values of the Dog	p. 8
References	p. 14
2 Husbandry	p. 17
Housing	p. 17
Facility Design Considerations	p. 17
Room Construction Features (Macroenvironment)	p. 18
Outdoor Housing	p. 20
Cage Materials and Design (Microenvironment)	p. 20
Cage Size Standards	p. 24
Environmental Conditions	p. 25
Animal Care	p. 26
Nutrition and Water	p. 26
Environmental Enrichment	p. 28
Exercise Requirements	p. 31
Sanitation	p. 32
Daily Schedule	p. 34
Weekly Schedule	p. 34
Semimonthly Schedule	p. 34
Room Sanitation Schedule	p. 35
Sanitation Quality Assurance Monitoring	p. 35
Animal Receipt	p. 36
Animal Identification	p. 37
Transportation	p. 39
Record Keeping	p. 40
Husbandry Records	p. 40
References	p. 43
3 Management	p. 45
Regulatory Agencies and Compliance	p. 45
U.S. Department of Agriculture	p. 45
Public Health Service, National Institutes of Health, and Office for Laboratory Animal Welfare	p. 46
U.S. Food and Drug Administration and U.S. Environmental Protection Agency Good Laboratory Practice Regulations	p. 47
The Association for Assessment and Accreditation of Laboratory Animal Care International	p. 47
State and Local Agencies	p. 48
Institutional Animal Care and Use Committee	p. 48
Occupational Health and Safety	p. 49
Zoonoses	p. 50
Rabies	p. 51
Scabies	p. 51
Intestinal Helminthes	p. 52
Giardiasis	p. 52
Infections Resulting from Bite Wounds	p. 52
Human-Animal Bond	p. 53
References	p. 54
4 Veterinary Care	p. 57
Preventative Health Program	p. 57
Sources	p. 57
Quarantine, Stabilization, and Acclimation	p. 58
Colony Separation	p. 59
Clinical Management	p. 59
Basic Veterinary Supplies	p. 59
The Physical Examination	p. 63
Clinical Signs of Illness in Dogs	p. 69
Common Clinical Problems	p. 70
Viral Diseases	p. 70
Canine Parvovirus	p. 70
Canine Distemper	p. 71
Canine Coronavirus	p. 72
Rabies	p. 72
Kennel Cough	p. 73
Bacterial Diseases	p. 73
Leptospirosis	p. 73
Parasitic Diseases	p. 74
Protozoa	p. 74
Nematodes	p. 74
Cestodes	p. 75
Arthropods	p. 75
Fleas	p. 75
Mites	p. 76
Lice	p. 76
Ticks	p. 77
Fungal Diseases	p. 77
Miscellaneous Diseases and Conditions	p. 77
Interdigital Cysts	p. 77
Juvenile Polyarteritis Syndrome: Beagle Pain Syndrome	p. 78
Cherry Eye	p. 78
Dental Conditions	p. 79
Obesity	p. 79
Implant Problems	p. 79
Traumatic Injuries	p. 80
Behavioral Disorders	p. 80
Treatment of Diseases	p. 80
General Treatment of Diarrhea	p. 81
General Treatment of Dehydration	p. 82
General Treatment of Anorexia	p. 83
Drug Dosages in Dogs	p. 83
Disease Prevention Through Sanitation	p. 83
Anesthesia, Analgesia, and Sedation	p. 84
Common Definitions	p. 86
Principles of General Anesthesia	p. 86
Stages of Anesthesia	p. 89
Stage I Voluntary Excitement	p. 89
Stage II Involuntary Excitement or Delirium	p. 89
Stage III Surgical Anesthesia	p. 89
Stage IV Medullary Paralysis and Respiratory Arrest	p. 91
Assessment of the Depth of Anesthesia	p. 91
Respiration	p. 91
Cardiovascular	p. 91
Reflexes	p. 91
Ocular	p. 92
Preanesthetic Management	p. 92
Characteristics of Commonly Used Preanesthetics	p. 93
Choosing an Anesthetic Regimen	p. 93
Characteristics of Commonly Used Injectable Anesthetics	p. 94
Principles of Gas Anesthesia	p. 94
Characteristics of Commonly Used Gas Anesthetics	p. 95
Principles of Local Anesthesia	p. 95
Aseptic Surgery	p. 96
Facilities, Features, and Equipment	p. 96
Endotracheal Intubation	p. 98
Personnel	p. 101
Preoperative Preparation	p. 101
Operating Room Procedures	p. 102
Postsurgical Management	p. 103
Guidelines for the Assessment of Signs of Pain in Animals	p. 104
Blood Donors	p. 104
Euthanasia	p. 105
Signs of Morbidity (State of Disease or Illness) in Animals	p. 105
Selected Criteria for Euthanasia of Moribund (State of Dying) Animals	p. 106
References	p. 107
5 Experimental Methodology	p. 109
Canine Handling and Restraint	p. 109
Mechanical Restraint Devices	p. 111
Sample Collection Methods	p. 112
Blood Collection	p. 112
Urine Collection	p. 116
Cerebrospinal Fluid Collection	p. 119
Collection of Feces	p. 120
Bone Marrow Collection	p. 121
Test Article/Compound Administration Techniques	p. 121
Formulation Guidelines	p. 121
Volume Guidelines	p. 122
Oral Dosing	p. 123
Injection Sites	p. 124
Implantable Osmotic Minipumps	p. 124
Telemetry	p. 125
Necropsy	p. 128
References	p. 130
6 Resources	p. 131
Organizations	p. 131
Publications	p. 138
Books	p. 138
Periodicals	p. 139
Electronic Resources	p. 140
Canine Sources	p. 141
Transportation Services/Resources	p. 142
Laboratory Services	p. 143
Feed	p. 143
Equipment	p. 144
Sanitation	p. 144
Cages, Research, and Veterinary Supplies	p. 145
Index	p. 149

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Summary

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Table of Contents