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Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
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Searching... | 30000010196703 | RS189 P74 2008 | Open Access Book | Book | Searching... |
Searching... | 30000010207651 | RS189 P74 2008 | Open Access Book | Book | Searching... |
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Summary
Summary
In the seven years since the publication of Principles and Practice of Bioanalysis bioanalytical methods have remained the same, but their usage patterns have changed. This second edition of a bestseller provides an updated guide to the techniques used in developing and running ultra-trace analyses for drugs, metabolites, and other substances.
Extensively revised, this volume reflects the dynamic growth in methodologies that has occurred over the past five years. Each chapter has been overhauled or re-written to reflect modern practice. Experts in the field offer a logical path through the problems of small molecule bioanalysis, enabling you to choose the appropriate methods of analysis across a number of fields, including the agrochemical and pharmaceutical industries. They cover a wide range of analytical methods, including mass spectrometry, liquid chromatography, immunoassay, NMR, and gas chromatography.
Presenting the information in an informal and highly accessible style, the book covers the theory and practice of bioanalysis, enabling you to gain maximum benefit and to optimize analytical methods. With practical advice and guidance, it delineates how to develop robust analytical methods for a range of compounds, both natural and synthetic. Using these insights, you can more easily recognize problems and quickly solve them.
Table of Contents
Preface to the Second Edition | p. vii |
Preface to the First Edition | p. ix |
About the Editor | p. xi |
Contributors | p. xiii |
Chapter 1 Physicochemical Properties of Drugs and Metabolites and Their Impact on Bioanalysis | p. 1 |
Chapter 2 Sample Preparation | p. 19 |
Chapter 3 Basic HPLC Theory and Practice | p. 41 |
Chapter 4 HPLC Optimisation | p. 69 |
Chapter 5 HPLC Detectors | p. 99 |
Chapter 6 Gas Chromatography: What It Is and How We Use It | p. 123 |
Chapter 7 Thin-Layer Chromatography | p. 141 |
Chapter 8 Immunoassay Techniques | p. 151 |
Chapter 9 Automation of Sample Preparation | p. 177 |
Chapter 10 Fundamental Aspects of Mass Spectrometry | p. 193 |
Chapter 11 Quantitative LC-MS | p. 223 |
Chapter 12 Mass Spectrometric Identification of Metabolites | p. 237 |
Chapter 13 Nuclear Magnetic Resonance in Drug Metabolism | p. 261 |
Chapter 14 Metabolite Isolation | p. 285 |
Chapter 15 Strategy for the Development of Quantitative Bioanalytical Procedures | p. 303 |
Index | p. 317 |