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Title:
Biodefense : research methodology and animal models
Publication Information:
Boca Raton, FL : CRC Press, 2006
ISBN:
9780849328367
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30000010101451 RC88.9.T47 B53 2006 Open Access Book Book
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Summary

Summary

The importance attached to rapidly developing our biodefensive capabilities has recently resulted in a significantly increased funding for biodefense research. Accordingly, researchers will respond with an effort equal to the challenge, producing an impressive body of findings.

To ensure that this effort continues in the most efficient manner, Biodefense: Research Methodology and Animal Models presents a thorough historical and current review of biodefense research, encouraging researchers to leverage relevant results, rather than duplicate them. By building on the work of others, scientists will be able to proceed in a way that makes the best use of available resources, while avoiding unnecessary duplication of animal research.

Including contributions from recognized leaders in the field who have developed and refined the animal models presented, this book examines those bacterial, viral, and toxic agents considered to pose the greatest threats to public safety. Each section on a specific agent provides pertinent background information, followed by a description of those animal models employed in research and testing and a discussion of how the findings translate to human impact.


Table of Contents

James W. MartinNelson W. RebertArthur O. Anderson and James R. SwearengenJaime B. Anderson and Kenneth TuckerChad J. Roy and Louise M. PittElizabeth K. Leffel and Louise M. PittDavid L. Fritz and David M. WaagJeffery J. Adamovicz and Patricia L. WorshamJeffery J. Adamovicz and Erica P. Wargo and David M. WaagDavid M. Waag and David L. FritzWilliam D. Pratt and Mary Kate Hart and Douglas S. Reed and Keith E. SteelePeter B. Jahrling and John W. HugginsKelly L. Warfield and Nancy K. Jaax and Emily M. Deal and Dana L. Swenson and Tom Larsen and Sina BavariStephen B. Greenbaum and Jaime B. AndersonStephen B. Greenbaum and Jaime B. AndersonTeresa Krakauer and Bradley G. Stiles
Chapter 1 The History of Biological Weaponsp. 1
Chapter 2 Bioterrorism and Biowarfare: Similarities and Differencesp. 13
Chapter 3 Scientific and Ethical Importance of Animal Models in Biodefense Researchp. 25
Chapter 4 Development and Validation of Animal Modelsp. 41
Chapter 5 Infectious Disease Aerobiology: Aerosol Challenge Methodsp. 61
Chapter 6 Anthraxp. 77
Chapter 7 Glandersp. 95
Chapter 8 Plaguep. 107
Chapter 9 Tularemiap. 137
Chapter 10 Q Feverp. 163
Chapter 11 Alphavirusesp. 181
Chapter 12 Orthopoxvirusesp. 207
Chapter 13 Viral Hemorrhagic Feversp. 227
Chapter 14 Botulinum Toxinsp. 259
Chapter 15 Ricinp. 275
Chapter 16 Staphylococcal and Streptococcal Superantigensp. 291
Indexp. 321