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Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
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Searching... | 30000010251163 | QP551 I68 2010 | Open Access Book | Book | Searching... |
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Summary
Summary
Human cells produce at least 30,000 different proteins. Each has a specific function characterized by a unique sequence and native conformation that allows it to perform that function. While research in this post-genomic era has created a deluge of invaluable information, the field has lacked for an authoritative introductory text needed to inform researchers and students in all of those fields now concerned with protein research.
Introduction to Peptides and Proteins brings together some of the most respected researchers in protein science to present a remarkably coherent introduction to modern peptide and protein chemistry. The first sections of the book delve into -
Basic peptide and protein science from assembly through degradation Traditional and emerging research methods including those used in bioinformatics and proteomics New computational approaches and algorithms used to find patterns in the vast data collected by sequencing projectsAfter providing a foundation in tools and methods, the authors closely examine six protein families, including representative classes such as enzymes, cell-surface receptors, antibodies, fibrous proteins, and bioactive peptide classes. They concentrate on biochemical mechanisms and where possible indicate therapeutic or biotechnical possibilities.
Then focusing on clinical aspects, the authors investigate misfolding as found in prion diseases, miscleavage as found in Alzheimer's, and mis-sequencing as found with some cancers. Drawing from some of their own research, the authors summarize recent achievements and emerging applications. They discuss the use of proteins and peptides as drugs and the solid-phase synthesis required for drug production. They also look at the use of peptides as functional biomolecules and research tools.
No longer just th
Author Notes
Langel, Ulo; Cravatt, Benjamin F.; Graslund, Astrid; von Heijne, N.G.H. ; Zorko, Matjaz; Land, Tiit; Niessen, Sherry
Table of Contents
Preface | p. ix |
Further Reading | p. xi |
Biography | p. xiii |
Introduction to Part I | p. 5 |
From Building Blocks to 3-D Structure | |
Chapter 1 Amino Acids | p. 5 |
Chapter 2 Noncovatent Interactions | p. 21 |
Chapter 3 Structural Organization of Proteins | p. 35 |
Protein Biosynthesis and Posttranslational Modifications | |
Chapter 4 The Biosynthesis of Proteins | p. 61 |
Chapter 5 Posttranslational Modifications | p. 81 |
Folding of Proteins | |
Chapter 6 Protein Folding | p. 101 |
Chapter 7 Intracellular Sorting of Proteins | p. 123 |
Protein Degradation | |
Chapter 8 Protein Turnover | p. 137 |
Introduction to Part IIAstrid Gräslund | |
Chapter 9 Purification and Characterization of Proteins | p. 147 |
Chapter 10 Crystallography and X-Ray Diffraction | p. 159 |
Chapter 11 Optical Spectroscopy | p. 167 |
Chapter 12 Nuclear Magnetic Resonance (NMR) | p. 177 |
Chapter 13 Methods to Follow Protein Folding | p. 189 |
Chapter 14 Mass Spectrometry | p. 195 |
Chapter 15 Chemical Synthesis of Peptides and Proteins | p. 199 |
Introduction to Part IIITiit Land | |
Chapter 16 Protein Engineering and Gene Silencing | p. 215 |
Chapter 17 Protein-Ligand Interactions | p. 229 |
Chapter 18 Sequence Analysis and Function Prediction | p. 245 |
Chapter 19 Protein Structure Prediction | p. 257 |
Chapter 20 Proteomics | p. 263 |
Introduction to Part IVÜlo Langel | |
Chapter 21 Enzymes | p. 283 |
Chapter 22 Nucleic Acid-Binding Proteins | p. 313 |
Chapter 23 Cell Surface Receptors and Signaling | p. 323 |
Chapter 24 Membrane Proteins | p. 337 |
Chapter 25 Antibodies | p. 343 |
Chapter 26 Fibrous Proteins | p. 355 |
Chapter 27 Selected Classes of Bioactive Peptides | p. 365 |
Introduction to Part VÜlo Langel and Astrid Gräslund | |
Chapter 28 Misfolding-Based Diseases | p. 381 |
Chapter 29 Miscleavage-Based Diseases | p. 389 |
Chapter 30 Missequence-Based Diseases | p. 395 |
Chapter 31 Peptides and Proteins as Drugs | p. 401 |
Index | p. 415 |