Kai-Uwe Lewandrowski and Gordon R. Bell and Robert F. McLainDavid G. HicksDaisuke Togawa and Kai-Uwe LewandrowskiRobert F. McLainSujith Kalmadi and Derek RaghavanRobert F. McLainDaniel Shedid and Edward C. BenzelEeric TruumeesA. Jay Khanna and Mesfin A. Lemma and Bruce A. Wasserman and Robert F. McLainA. Jay Khanna and Michael K. Shindle and Bruce A. WassermanKai-Uwe Lewandrowski and Robert F. McLain and Henry J. MankinTarek Mekhail and Rony Abou-Jawde and Maurie MarkmanMohamad HusseinRonald M. SobecksJohn Hill and G. Thomas BuddRobert DreicerMellar P. DavisJigar Shah and Tarek MekhailAjay Sood and S. Sethu ReddyRex C. Haydon and Frank M. PhillipsMohamed A. Elshaikh and Roger M. MacklisAdir LudinRichard L. CrownoverThomas F. DeLaney and Michael J. Harris and Francis J. Hornicek and Robert F. McLainIain H. KalfasPaul Park and Frank LaMarca and Robert F. McLainMichael P. Steinmetz and Anis O. Mekhail and Edward C. BenzelKeith R. Lodhia and Paul Park and Gregory P. GrazianoAshley R. Poynton and Mark H. Bilsky and Federico P. Girardi and Patrick J. Boland and Frank P. Cammisa, Jr.L. Brett Babat and Robert F. McLainDaryl R. Fourney and Ziya L. GokaslanDaniel Shedid and Edward C. BenzelJean-Valery C. E. Coumans and A. Jay Khanna and Isador H. LiebermanMark H. Bilsky and Todd Vitaz and Patrick BolandGordon R. BellBranco Prpa and Robert F. McLainRex A. W. Marco and Howard S. AnKai-Uwe Lewandrowski, Robert F. McLain and Edward C. BenzelLeah Moinzadeh and Sandee PattiSusan B. LeGrand and Declan WalshRichard Placide and Kai-Uwe Lewandrowski and Robert F. McLainEdward C. Benzel and Michael P. Steinmetz and Ann M. Henwood and L. Brett Babat and Anis O. Mekhail

Preface	p. v
Contributors	p. ix
1 Cancer of the Spine: How Big Is the Problem?	p. 1
2 Metastatic Disease to the Musculoskeletal System	p. 7
3 The Pathophysiology of Spinal Metastases	p. 17
4 Tumor Behavior: Barriers to Growth and Spread	p. 25
5 Fundamentals of Cancer Treatment: Effects of Chemotherapy on Neoplastic Cells	p. 31
6 The Role of Surgical Therapy: Principles of Effective Surgical Treatment	p. 43
7 Presenting History and Common Symptoms of Spine Tumors	p. 49
8 Physical Examination: Signs of Pathology and the Spine Examination	p. 55
9 Imaging: Screening for Spinal Disease	p. 67
10 Imaging of the Spine	p. 73
11 Laboratory Studies and Diagnostic Work-Up of Bony Lesions in the Spine	p. 83
12 Principles of Medical Management	p. 93
13 Multiple Myeloma and Plasmacytoma	p. 101
14 Lymphoma	p. 107
15 Metastatic Breast Carcinoma	p. 117
16 Genitourinary Oncology: Prostate, Renal, and Bladder Cancer	p. 123
17 Spinal Metastases From Gastrointestinal Malignancies	p. 131
18 Lung Cancer	p. 141
19 Medical Management of Thyroid Cancer	p. 157
20 Carcinoma of the Unknown PrimaryThomas E. Hutson and Ronald M. Bukowski
21 Primary Tumors of the Spine	p. 171
22 Common Radiotherapy Techniques for Spinal Tumors	p. 189
23 Spinal Radiotherapy for the Pediatric Patient: Indications, Special Technical Considerations, and Long-Term Consequences	p. 197
24 Conformal Radiotherapy for Spinal Lesions	p. 205
25 Photon- and Proton-Beam Radiotherapy in the Treatment of Spine Tumors	p. 211
26 Spinal Metastasis: Indications for Surgery	p. 219
27 Biopsy: Principles and Approaches	p. 227
28 Problem-Based Decision Making	p. 233
29 Spinal Cord and Nerve Root Decompression	p. 239
30 Metastatic Disease of the Cervical Spine	p. 247
31 Metastatic Disease of the Thoracolumbar Spine	p. 255
32 Complex Lumbosacral Resection and Reconstruction Procedure	p. 265
33 Neoplastic Disease of the Spinal Cord and the Spinal Canal	p. 279
34 Minimally Invasive Approaches to Spine Metastases: Endoscopic Surgery and Vertebral Augmentation	p. 285
35 Single-Stage Posterolateral Transpedicle Approach With Circumferential Decompression and Instrumentation for Spinal Metastases	p. 295
36 Primary Benign Spinal Tumors	p. 303
37 Surgical Treatment of Primary Malignant Tumors	p. 311
38 Complications of Surgical and Medical Care: Anticipation and Management	p. 323
39 Bracing for Patients With Spinal Tumors	p. 337
40 Rehabilitation in Patients With Tumors of the Spinal Column	p. 343
41 The Management of Pain in Spinal Malignancies	p. 349
42 Surveillance and Screening During Disease-Free Survival	p. 361
43 When is Enough, Enough?	p. 365
Index	p. 371