Title:
Stable nanoemulsions : self-assembly in nature and nanomedicine
Personal Author:
Series:
Studies in interface science ; 25
Publication Information:
Amsterdam : Elsevier, c2011
Physical Description:
xx, 415 p. : ill. ; 24 cm.
ISBN:
9780444537980
Available:*
Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
|---|---|---|---|---|---|
Searching... | 30000010279618 | TP156.E6 D374 2011 | Open Access Book | Book | Searching... |
On Order
Summary
Summary
This title is a greatly expanded and updated second edition of the original volume published by Elsevier in 1986. New material has been integrated with the original content in an organized and comprehensive manner.
Five new chapters have been included, which review over one and a half decades of research into lipid-coated microbubbles (LCM) and their medical applications. The new chapters contain much experimental data, which is examined in detail, along with relevant current literature.
This current edition builds on the original work in effectively filling the gap in the market for a comprehensive account of the surfactant stabilization of coated microbubbles.
Table of Contents
| Part I Natural Coated Microbubbles in the Biosphere |
| 1 Occurrence of dilute gas-in-liquid emulsions in natural waters |
| 2 Early work with aqueous carbohydrate gels |
| 3 Comparison of aqueous soil extracts with carbohydrate gels |
| 4 Characteristic glycopeptide fraction of natural microbubble surfactant |
| Part II Physicochemical Properties of Natural Microbubble Surfactant |
| 5 Ecological chemistry of microbubble surfactant |
| 6 Surface properties of microbubble-surfactant monolayers |
| 7 Structure of predominant surfactant components stabilizing natural microbubbles |
| 8 Stable microbubbles in physiological fluids: competing hypotheses |
| Part III Physicochemical Properties of Artificial Coated Microbubbles and Nanoparticles |
| 9 Concentrated gas-in-liquid emulsions in artificial media |
| I Demonstration by laser-light scattering |
| 10 Concentrated gas-in-liquid emulsions in artificial media |
| II Characterization by photon correlation spectroscopy |
| 11 Concentrated gas-in-liquid emulsions in artificial media |
| III Review of molecular mechanisms involved in microbubble stabilization |
| Part IV Lipid-Coated Microbubbles and Related Lipid Nanoparticles in Biomedical Studies on Animals |
| 12 Targeted imaging of tumors, and targeted cavitation therapy, with lipid-coated microbubbles (LCM) |
| 13 Targeted drug-delivery therapy of tumors using LCM |
| 14 Proposed mechanism of selective LCM uptake by tumor cells: role of lipoprotein receptor-mediated endocytic pathways |
| 15 Endocytotic events versus particle size: multidisciplinary analyses demonstrate LCM sizes are mostly submicron |
| Part V Self-Assembling Mixed-Lipid Microbubbles and Nanoparticles for Clinical Applications |
| 16 LCM and nanoparticle subpopulations for drug delivery |
| 17 Composition of LCM governing interplay with nanoparticle subpopulation |
| 18 Targeted nanoparticle subpopulation: comparison with self-nanoemulsifying drug-delivery systems in pharmaceutical research |
| 19 Clinical development of a "LCM/nanoparticle-derived" formulation: a nanoemulsion based upon "dispersed LMN" |
| 20 Selected parenteral lipid nanoemulsions under clinical study: comparison concerning passive accumulation in tumors, active targeting of tumors, and validation status |
| 21 Supplementary operational benefits concerning "LCM/nanoparticle-derived" formulations: relation to lipid-nanoemulsion structure |
| Part VI "LCM/Nanoparticle-Derived" Nanoemulsions: Biological Lipid Polymorphism, and Receptor Mediated Endocytosis, used for Clinical Study |
| 22 Biological lipid polymorphs: preferred cubic phase of "dispersed LMN" |
| 23 Non-lamellar phase(s) facilitating membrane fusion: endocytosis of dispersed LMN |
| 24 Receptor-mediated endocytosis of (mixed-lipid) dispersed LMN |
| 25 Further chemotherapy with lipid nanoemulsions: targeting certain proliferative processes, as well as neoplasias, via "lipoprotein receptor"-mediated endocytosis |
| 26 Related clinical trials and human epidemiological studies |
| 27 Aspects of future R&D regarding targeted lipid nanoemulsions |
