Cover image for Clinical chemistry research
Title:
Clinical chemistry research
Publication Information:
New York : Nova Biomedical, c2009
Physical Description:
xiv, 376 p. : ill. ; 26 cm.
ISBN:
9781606925171

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30000010237888 RS403 C54 2009 Open Access Book Book
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Summary

Summary

Among many research topics, this book considers phytoestrogens, natural compounds found in plants that possess oestrogen-like activity. Despite the growing evidence of the health benefits of phytoestrogens, further investigation is needed to better understand their mechanism of actions, the biological outcomes and possible adverse effects. This book chapter summarises the most recent developments of lanthanide nanorods in the field of biomedical nanotechnology. The cellular uptake of nanoparticles as a function of several parameters, such as polymeric material and surfactant type are considered. Camptothecins (CPTs) are regarded as one of the most promising anticancer drugs of the twenty-first century. A further chapter describes SAR, QSAR, and the clinical chemistry of CPT derivatives to understand their chemical-biological interactions and side effects. This book addresses the biological and pharmacological significances of identification and analysis of effective components of natural medicines and describes methods and procedures for identification and analysis. Potential future prospects in the field are provided. The porphyrazines are an emerging class of compounds exhibiting tremendous potential for use as anti-tumour therapeutic agents and in imaging applications. This book reviews the initial structure-function studies that have been carried out to date on this little-studied class of compounds. A further study hypothesises that the differences in the biology of breast cancers observed in women of different races are partially related to differences in the secretory activity of adipocytes in the breast tissue. The possible role of adipokines in breast malignancies of women of various races is reviewed.


Table of Contents

Rita de Cássia da Silveira e Sá and Luciana Valente BorgesRajeskwar P. Verma and Corwin HanschChitta Ranjan Patra and Priyabrata Mukherjee and Debabrata MukhopadhyayChenggang Huang and Chunhui Ma and Yihong Tang and Yuanyuan ZhangSherry Sze Yee Ho and Sonia Baig and Sukumar Ponnusamy and Mahesh ChoolaniAnna Musyanovych and Katharina Landfester and Volker MailänderMichael EisenhutBernhard Aigner and Birgit Rathkolb and Eckhard WolfJixin Yang and Jiexiong FengB.J. Vesper and A.G.M. Barrett and B. M. Hoffman and J. A. RadosevichSimone KönigGiulio Ferino and Giovanna Delogu and Gianni Podda and Eugenio Uriarte and Humberto González-DíazFrancis O. Ikpatt and Errol Berman and Arpad SzallasiHaruhiro Muratsubaki and Keiichiro EnomotoNadia Habal and Mark Feldman
Prefacep. vii
Chapter I Phytoestrogens: Biochemical Aspects and Biological Activitiesp. 1
Chapter II (Q)SAR and Clinical Chemistry of Camptothecin Analoguesp. 57
Chapter III Application of Lanthanide (Ln = Eu & Tb) Nanoparticles in Biology and Medicinep. 99
Chapter IV Identification and Analysis of Effective Components in Animal Biofluids Following Administration of Natural Medicinesp. 143
Chapter V Frontiers of Molecular Technologies in Noninvasive Prenatal Diagnosisp. 177
Chapter VI Polymeric Nanoparticles as Carrier Systems: How Does the Material and Surface Charge Affect Cellular Uptake?p. 195
Chapter VII The Role of 1, 25 Dihydroxy-Vitamin D3 in Immunity to Infectious Diseasep. 221
Chapter VIII Generation and Analysis of Disease-Specific Mouse Models by Clinical Chemical Screeningp. 239
Chapter IX Gene Therapy of Congenital Diseases: Applications, Problems and Prospectsp. 261
Chapter X Porphyrazine Anti-Tumor Agentsp. 281
Expert Commentaryp. 301
Mass Spectrometry in Clinical Chemistryp. 301
Short Communicationsp. 305
Quantitative Proteome-Disease Relationships (QPDRs) in Clinical Chemistry: Prediction of Prostate Cancer with Spectral Moments of PSA/MS Star Networksp. 307
Not So Innocent - Adipocytes May Explain Racial Differences in Breast Cancer: Implications for Clinical Chemistryp. 319
Analytical Method of Allantoin Detection in Human Sera and the Clinical Significance of this Measurementp. 327
Relationship between Serum Creatine Kinase Activity and Serum Aminotransferase Activity in Patients with Extensive Rhabdomyolysis or Myocardial Necrosisp. 335
Indexp. 343