Title:
Spectroscopy of pharmaceutical solids
Series:
Drugs and pharmaceutical sciences ; 160
Publication Information:
New York : Informa Healthcare, 2006
ISBN:
9781574448931
Added Author:
Available:*
Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
---|---|---|---|---|---|
Searching... | 30000010127119 | RS201.S57 S63 2006 | Open Access Book | Book | Searching... |
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Summary
Summary
Selecting illustrative examples from the recent literature, this reference studies the underlying principles and physics of a wide range of spectroscopic techniques utilized in the pharmaceutical sciences and demonstrates various applications for each method analyzed in the text-showing how knowledge of the mechanisms of spectroscopic phenomena may facilitate more advanced technologies in the field.
Author Notes
Brittain, Harry G.
Table of Contents
Preface | p. iii |
Contributors | p. ix |
Part I Introduction to Spectroscopy | |
1 Electromagnetic Radiation and Spectroscopy | p. 1 |
Nature of Electromagnetic Radiation | p. 1 |
Classical Description of Electromagnetic Radiation | p. 3 |
The Quantum Theory of Electromagnetic Radiation | p. 8 |
Ionization and Excitation of Atoms | p. 12 |
Development of the Quantum Theory | p. 17 |
Overview of Spectroscopy | p. 28 |
Summary | p. 30 |
References | p. 31 |
Part II Core Electron Spectroscopy | |
2 Core Electron States and X-Ray Absorption Spectroscopy | p. 33 |
Wave Mechanical Description of the Hydrogen Atom | p. 33 |
X-Ray Absorption Spectroscopy | p. 53 |
References | p. 64 |
3 X-Ray Photoelectron and X-Ray Fluorescence Spectroscopy | p. 67 |
X-Ray Emission Spectroscopies | p. 67 |
X-Ray Photoelectron Spectroscopy | p. 69 |
X-Ray Fluorescence Spectroscopy | p. 77 |
References | p. 87 |
Part III Valence Electron Spectroscopy | |
4 Molecular Orbital Theory and the Electronic Structure of Molecules | p. 91 |
Molecular Orbital (MO) Theory of Organic Molecules | p. 91 |
LCAO-MO Theory | p. 93 |
LCAO-MO Theory and the Spectroscopy of Diatomic Molecules | p. 97 |
MO Theory and the Spectroscopy of Polyatomic Molecules | p. 104 |
General Features of the Absorption Spectroscopy of Organic Molecules | p. 112 |
References | p. 119 |
5 UV/VIS Reflectance Spectroscopy | p. 121 |
Introduction | p. 121 |
Categories of Light Reflectance | p. 122 |
Theory Associated with Diffuse Reflectance Measurements | p. 124 |
Instrumentation for the Measurement of Diffuse Reflectance | p. 127 |
Quantitative Measurement of Color | p. 129 |
Applications of UV/VIS Diffuse Reflectance Spectroscopy to the Study of Solids Having Pharmaceutical Interest | p. 134 |
Use of Adsorbed Indicators for the Evaluation of Surface Acidity and Basicity | p. 141 |
Summary | p. 147 |
References | p. 147 |
6 Luminescence Spectroscopy | p. 151 |
Introduction | p. 151 |
Photophysical Processes in Isolated Organic Molecules | p. 152 |
Photophysical Processes Associated with Interacting Molecules | p. 157 |
Instrumentation for the Measurement of Luminescence Spectra | p. 170 |
Photoluminescence and the Structure of Organic Molecules | p. 178 |
Studies of Luminescence in the Crystalline State | p. 179 |
Photoluminescence from Molecules Adsorbed on Surfaces | p. 184 |
References | p. 198 |
Part IV Vibrational Level Spectroscopy | |
7 Molecular Motion and Vibrational Spectroscopy | p. 205 |
Introduction | p. 205 |
Motion of Nuclei in Molecules | p. 206 |
Rotation and Vibration in Diatomic Molecules | p. 210 |
Vibrational Energy Levels and Spectroscopy of Diatomic Molecules | p. 213 |
Vibrational Energy Levels and Spectroscopy of the Fundamental Transitions of Polyatomic Molecules | p. 219 |
Spectroscopy of Transitions Associated with Overtones and Combinations of Fundamental Vibrational Modes | p. 227 |
Summary | p. 231 |
References | p. 232 |
8 Infrared Absorption Spectroscopy | p. 235 |
Introduction | p. 235 |
Some Fundamental Principles of IR Absorption Spectroscopy | p. 236 |
Instrumentation for the Measurement of IR Spectra in the Solid State | p. 239 |
Applications of IR Spectroscopy to Areas of Pharmaceutical Interest | p. 246 |
References | p. 265 |
9 Raman Spectroscopy | p. 271 |
Introduction | p. 271 |
Some Fundamental Principles of the Raman Effect | p. 272 |
Instrumentation for Measurement of Raman Spectra in the Solid State | p. 278 |
Group Frequency Correlations in Raman Spectroscopy and Effects of the Solid State | p. 283 |
Applications of Raman Spectroscopy to Areas of Pharmaceutical Interest | p. 286 |
References | p. 309 |
10 Near-Infrared Spectroscopy | p. 313 |
Introduction | p. 313 |
Fundamental Principles | p. 315 |
Practice of NIR Spectroscopy | p. 344 |
Applications in Pharmaceutical Solids Analysis | p. 389 |
References | p. 406 |
Part V Nuclear Spin Level Spectroscopy | |
11 Solid-State Nuclear Magnetic Resonance Spectrometry | p. 413 |
Fundamental Principles of NMR | p. 413 |
SSNMR of Powder Solids | p. 420 |
Pharmaceutically Relevant Applications of SSNMR | p. 427 |
References | p. 538 |
Index | p. 559 |