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Cover image for Spectroscopy of pharmaceutical solids
Title:
Spectroscopy of pharmaceutical solids
Series:
Drugs and pharmaceutical sciences ; 160
Publication Information:
New York : Informa Healthcare, 2006
ISBN:
9781574448931
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30000010127119 RS201.S57 S63 2006 Open Access Book Book
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Summary

Summary

Selecting illustrative examples from the recent literature, this reference studies the underlying principles and physics of a wide range of spectroscopic techniques utilized in the pharmaceutical sciences and demonstrates various applications for each method analyzed in the text-showing how knowledge of the mechanisms of spectroscopic phenomena may facilitate more advanced technologies in the field.


Author Notes

Brittain, Harry G.


Table of Contents

Harry G. BrittainHarry G. BrittainHarry G. BrittainHarry G. BrittainHarry G. BrittainHarry G. BrittainHarry G. BrittainDavid E. Bugay and Harry G. BrittainDavid E. Bugay and Harry G. BrittainRobert P. Cogdill and James K. Drennen, IIIAles Medek
Prefacep. iii
Contributorsp. ix
Part I Introduction to Spectroscopy
1 Electromagnetic Radiation and Spectroscopyp. 1
Nature of Electromagnetic Radiationp. 1
Classical Description of Electromagnetic Radiationp. 3
The Quantum Theory of Electromagnetic Radiationp. 8
Ionization and Excitation of Atomsp. 12
Development of the Quantum Theoryp. 17
Overview of Spectroscopyp. 28
Summaryp. 30
Referencesp. 31
Part II Core Electron Spectroscopy
2 Core Electron States and X-Ray Absorption Spectroscopyp. 33
Wave Mechanical Description of the Hydrogen Atomp. 33
X-Ray Absorption Spectroscopyp. 53
Referencesp. 64
3 X-Ray Photoelectron and X-Ray Fluorescence Spectroscopyp. 67
X-Ray Emission Spectroscopiesp. 67
X-Ray Photoelectron Spectroscopyp. 69
X-Ray Fluorescence Spectroscopyp. 77
Referencesp. 87
Part III Valence Electron Spectroscopy
4 Molecular Orbital Theory and the Electronic Structure of Moleculesp. 91
Molecular Orbital (MO) Theory of Organic Moleculesp. 91
LCAO-MO Theoryp. 93
LCAO-MO Theory and the Spectroscopy of Diatomic Moleculesp. 97
MO Theory and the Spectroscopy of Polyatomic Moleculesp. 104
General Features of the Absorption Spectroscopy of Organic Moleculesp. 112
Referencesp. 119
5 UV/VIS Reflectance Spectroscopyp. 121
Introductionp. 121
Categories of Light Reflectancep. 122
Theory Associated with Diffuse Reflectance Measurementsp. 124
Instrumentation for the Measurement of Diffuse Reflectancep. 127
Quantitative Measurement of Colorp. 129
Applications of UV/VIS Diffuse Reflectance Spectroscopy to the Study of Solids Having Pharmaceutical Interestp. 134
Use of Adsorbed Indicators for the Evaluation of Surface Acidity and Basicityp. 141
Summaryp. 147
Referencesp. 147
6 Luminescence Spectroscopyp. 151
Introductionp. 151
Photophysical Processes in Isolated Organic Moleculesp. 152
Photophysical Processes Associated with Interacting Moleculesp. 157
Instrumentation for the Measurement of Luminescence Spectrap. 170
Photoluminescence and the Structure of Organic Moleculesp. 178
Studies of Luminescence in the Crystalline Statep. 179
Photoluminescence from Molecules Adsorbed on Surfacesp. 184
Referencesp. 198
Part IV Vibrational Level Spectroscopy
7 Molecular Motion and Vibrational Spectroscopyp. 205
Introductionp. 205
Motion of Nuclei in Moleculesp. 206
Rotation and Vibration in Diatomic Moleculesp. 210
Vibrational Energy Levels and Spectroscopy of Diatomic Moleculesp. 213
Vibrational Energy Levels and Spectroscopy of the Fundamental Transitions of Polyatomic Moleculesp. 219
Spectroscopy of Transitions Associated with Overtones and Combinations of Fundamental Vibrational Modesp. 227
Summaryp. 231
Referencesp. 232
8 Infrared Absorption Spectroscopyp. 235
Introductionp. 235
Some Fundamental Principles of IR Absorption Spectroscopyp. 236
Instrumentation for the Measurement of IR Spectra in the Solid Statep. 239
Applications of IR Spectroscopy to Areas of Pharmaceutical Interestp. 246
Referencesp. 265
9 Raman Spectroscopyp. 271
Introductionp. 271
Some Fundamental Principles of the Raman Effectp. 272
Instrumentation for Measurement of Raman Spectra in the Solid Statep. 278
Group Frequency Correlations in Raman Spectroscopy and Effects of the Solid Statep. 283
Applications of Raman Spectroscopy to Areas of Pharmaceutical Interestp. 286
Referencesp. 309
10 Near-Infrared Spectroscopyp. 313
Introductionp. 313
Fundamental Principlesp. 315
Practice of NIR Spectroscopyp. 344
Applications in Pharmaceutical Solids Analysisp. 389
Referencesp. 406
Part V Nuclear Spin Level Spectroscopy
11 Solid-State Nuclear Magnetic Resonance Spectrometryp. 413
Fundamental Principles of NMRp. 413
SSNMR of Powder Solidsp. 420
Pharmaceutically Relevant Applications of SSNMRp. 427
Referencesp. 538
Indexp. 559
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