Modeling and simulation in biomedical engineering : applications in cardiorespiratory physiology

Title:

Personal Author:

Meurs, Willem van, 1962-

Publication Information:

New York : McGraw-Hill, c2011

Physical Description:

xx, 193 p. : ill. ; 23 cm.

ISBN:

9780071714457

Abstract:

"This guide comprehensively covers everything from theory to practical application examples of modeling and simulation techniques of human physiology for medical engineers"--Provided by publisher

Subject Term:

Cardiopulmonary system -- Computer simulation

Cardiopulmonary system -- Mathematical models

Biomedical engineering -- Methodology

Available:*

Library	Item Barcode	Call Number	Material Type	Item Category 1	Status
Searching... PSZ JB	30000010279613	QP112.4 M48 2011	Open Access Book	Book	Searching... Unknown

Summary

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.

THEORY AND PRACTICE OF MODELING AND SIMULATING HUMAN PHYSIOLOGY

Written by a coinventor of the Human Patient Simulator (HPS) and past president of the Society in Europe for Simulation Applied to Medicine (SESAM), Modeling and Simulation in Biomedical Engineering: Applications in Cardiorespiratory Physiology is a compact and consistent introduction to this expanding field. The book divides the modeling and simulation process into five manageable steps--requirements, conceptual models, mathematical models, software implementation, and simulation results and validation.

A framework and a basic set of deterministic, continuous-time models for the cardiorespiratory system are provided. This timely resource also addresses advanced topics, including sensitivity analysis and setting model requirements as part of an encompassing simulation and simulator design. Practical examples provide you with the skills to evaluate and adapt existing physiologic models or create new ones for specific applications.

Coverage includes:

Signals and systems Model requirements Conceptual models Mathematical models Software implementation Simulation results and model validation Cardiorespiratory system model Circulation Respiration Physiologic control Sensitivity analysis of a cardiovascular model Design of model-driven acute care training simulators

"Uniquely qualified to author such a text, van Meurs is one of the original developers of CAE Healthcare's Human Patient Simulator (HPS). ...His understanding of mathematics, human physiology, pharmacology, control systems, and systems engineering, combined with a conversational writing style, results in a readable text. ...The ample illustrations and tables also break up the text and make reading the book easier on the eyes. ...concise yet in conversational style, with real-life examples. This book is highly recommended for coursework in physiologic modeling and for all who are interested in simulator design and development. The book pulls all these topics together under one cover and is an important contribution to biomedical literature." -- IEEE Pulse , January 2014

"This book is written by a professional engineer who is unique in that he seems to have a natural understanding of 3 key areas as follows: the hardware involved with simulators, human physiology, and mathematical modeling. Willem van Meurs is one of the inventors of the model-driven human patient simulator (HPS), and so, he is very qualified to write this book. The book is written in a clear way, using the first person throughout, in a conversational manner, with a style that involves posing questions and answering them in subsequent text. ...The book starts with a very useful introduction and background chapter, setting out the scene for the rest of the book. ...I have used his book in enhancing my own talks and understanding human patient simulation and can strongly recommend it." -- Simulation in Healthcare December, 2012
Reviewed by Mark A. Tooley, Ph.D., Department of Medical Physics and Bioengineering, Royal United Hospital, Combe Park, Bath, UK.

Author Notes

Willem van Meurs, Ph.D., is the co-inventor of the Human Patient Simulator. He is a consultant at Medical Education Technologies, Inc., and conducts modeling and simulation teaching and research at the University of Porto, Portugal. Dr. van Meurs was the president of the Society in Europe for Simulation Applied to Medicine from 2005-2007. He has published more than 20 full papers in peer-reviewed international journals and books and co-authored eight U.S. patents on modeling and simulation techniques.

Foreword	p. xv
Preface	p. xvii
Acknowledgments	p. xix
1 Introduction	p. 1
1.1 Signals and Systems	p. 3
1.2 System Properties	p. 5
SISO and MIMO	p. 5
Continuous-Time and Discrete-Time	p. 5
Static and Dynamic	p. 6
Linear and Nonlinear	p. 6
Time-Invariant and Time-Variant	p. 6
1.3 Modeling and Simulation	p. 7
1.4 Applications in Biomedical Engineering	p. 10
1.5 Symbolic Notation	p. 11
Review Problems	p. 12
References and Further Reading	p. 12
Part 1 Theory
2 Model Requirements	p. 17
2.1 Qualitative Aspects	p. 19
2.2 Quantitative Aspects	p. 22
2.3 Implementation and Interfacing	p. 24
Model Code Implementation	p. 24
Interfacing	p. 24
General Program Requirements	p. 27
2.4 Target Response Data	p. 27
Review Problems	p. 28
References and Further Reading	p. 29
3 Conceptual Models	p. 31
3.1 Block Diagrams	p. 34
3.2 Component Diagrams	p. 39
3.3 General Observations on Conceptual Models	p. 42
Review Problems	p. 43
References and Further Reading	p. 43
4 Mathematical Models	p. 45
4.1 A Model of Two Physical Systems	p. 47
4.2 State Variable Models	p. 51
4.3 Units and Numerical Values	p. 56
4.4 Direct Representation of Fluid Circuits	p. 58
4.5 Direct Representation of Gas Uptake and Distribution	p. 63
4.6 Direct Representation of Simple Transfers in the Nervous System	p. 70
4.7 Electrical Analogs and State Variable Models of Circuits	p. 70
4.8 General Observations on Mathematical Models and Parameter Estimation	p. 77
Review Problems	p. 79
References and Further Reading	p. 80
5 Software Implementation	p. 81
5.1 Discretization of the Continuous-Time State Equation	p. 83
5.2 Basic Algorithms for Implementation of the Discrete-Time State Variable Model	p. 84
5.3 Model Code Verification	p. 86
5.4 Connecting State Variable Models	p. 87
Review Problems	p. 93
References and Further Reading	p. 94
6 Simulation Results and Model Validation	p. 95
6.1 Definitions and Overall Procedure	p. 97
6.2 Quantitative and Qualitative Methods for Establishing Accuracy	p. 100
6.3 Range of Validity, Target Data, and Experimental Conditions	p. 102
Review Problems	p. 103
References and Further Reading	p. 103
Part II Applications
7 A Model of the Cardiorespiratory System	p. 107
7.1 Model Requirements	p. 110
7.2 Conceptual Model	p. 111
Reference and Further Reading	p. 113
8 Circulation	p. 115
8.1 Model Requirements	p. 117
8.2 Conceptual Models	p. 119
8.3 Mathematical Models	p. 122
References and Further Reading	p. 131
9 Respiration	p. 133
9.1 Model Requirements	p. 133
9.2 Multiple Models	p. 135
9.3 Conceptual Models	p. 137
9.4 Mathematical Models	p. 145
References and Further Reading	p. 154
10 Physiologic Control	p. 155
10.1 Model Requirements	p. 158
10.2 Conceptual Models	p. 160
10.3 Mathematical Models	p. 162
References and Further Reading	p. 168
Part III Advanced Topics
11 Sensitivity Analysis	p. 169
11.1 Method	p. 171
11.2 Application to a Hemodynamic Model	p. 172
References and Further Reading	p. 174
12 Design of Model-Driven Acute Care Training Simulators	p. 175
12.1 Training Program Design	p. 178
12.2 Simulator Design	p. 180
12.3 Model Requirements	p. 182
References and Further Reading	p. 185
Index	p. 187

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Summary

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Author Notes

Table of Contents