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Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
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Searching... | 30000004589846 | QP171 M47 2005 | Open Access Book | Book | Searching... |
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Summary
Summary
Metabolism By In Vivo NMR reviews and extends the experimental and theoretical reports concerning in vivo NMR, a pioneering approach that offers versatile new ways of studying metabolic pathways. Perfectly timed to coincide with recent findings that demonstrate the novelty and strength of this approach, the book covers recent applications in biochemistry, medicine, and psychology; in vivo NMR techniques; MCA; glucose metabolism focusing on glycogen; the value of muscle glycogen measurements in exercise; and much more. This book is unique in linking in vivo 13C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states Provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disorders Novel and potentially controversial Will inspire future research directions.
Author Notes
Editors: Robert G. Shulman and Douglas L. Rothman , Yale University School of Medicine, New Haven, Connecticut, USA
Table of Contents
Contributors |
ForewordSir George K. Radda |
Section A Background |
1 IntroductionRobert G. Shulman |
2 In Vivo NMR Spectroscopy - Techniques; Direct Detection; MRS; Kinetics and Labels; Fluxes; ConcentrationsRobin de Graaf |
3 Metabolic Control Analysis for the NMR SpectroscopistDavid A. Fell |
Section B 13 C and 31 P NMR Studies of the Regulation of Glucose Metabolism |
4 MRS Studies of the Role of the Muscle Glycogen Synthesis Pathway in the Pathophysiology of Type 2 DiabetesGerald I. Shulman and Douglas L. Rothman |
5 Phosphorylation of Allosteric Enzymes can serve Homeostasis rather than Control Flux: the Example of Glycogen SynthaseJames R.A. Schafer and David A. Fell and Douglas Rothman and Robert G. Shulman |
6 Regulation of Glycogen Metabolism in Muscle during ExerciseThomas B. Price |
7 13 C NMR Studies of Heart Glycogen MetabolismMaren R. Laughlin and Douglas L. Rothman and Robert G. Shulman |
8 Bioenergetics Implication of Metabolic Fluctuation during Muscle ContractionThomas Jue |
9 Lactate, Glycogen and FatigueRobert G. Shulman and Douglas L. Rothman |
10 Futile Cycling in Yeast: How to Control Gluttony in the Midst of PlentyJan den Hollander and Robert G. Shulman |
11 Trehalose Energetics in Yeast SporesRobert G. Shulman and Jan den Hollander |
12 Metabolic Networks in the Liver by 2 H and 13 C NMRA. Dean Sherry and Craig R. Malloy |
13 Summarized Reflections on MetabolismRobert G. Shulman and James R. A. Schafer |
Index |