Introduction to proteins : structure, function, and motion

Title:

Personal Author:

Kessel, Amit

Series:

Chapman & Hall/CRC mathematical and computational biology series

Chapman & Hall/CRC mathematical and computational biology series (Unnumbered)

Publication Information:

Boca Raton : CRC Press, 2011

Physical Description:

xxvii, 626 p. : ill. ; 26 cm.

ISBN:

9781439810712

Abstract:

"The book aims to provide the reader with a detailed description of protein structure and dynamics, combined with an in-depth discussion of the relationship between both these aspects and protein function. Adopting the structural-biophysical approach, we discuss these in relation to molecular interactions and thermodynamic changes that transpire in this highly complex system. There are several types of textbooks describing protein structure and function. Biochemistry textbooks emphasize the functional aspect of proteins and provide a rather general description of structure and structure-function relationship (SFR). Structural Biology textbooks provide an extensive description of protein structure and also refer to SFR with varying degrees of detail. However, energy-related aspects are often avoided. Molecular biophysics textbooks focus on molecular interactions and thermodynamic aspects of protein structure, but tend to lack detailed description of structural and dynamic aspects, as well as SFR. Our book refers to all of the aforementioned aspects and attempts to provide a unified view. Our energy-oriented approach is manifested throughout the book, whether we discuss structure, dynamics or specific functions of proteins. An extensive discussion of the energetics of protein structure is also given in a chapter dedicated to this topic"--Provided by publisher.

Subject Term:

Proteins

Proteins -- Structure-activity relationships

Physical biochemistry

Proteins -- Physiology

Amino Acid Sequence

Protein Conformation

Added Author:

Ben-Tal, Nir

Available:*

Library	Item Barcode	Call Number	Material Type	Item Category 1	Status
Searching... PSZ JB	30000010265268	QP551 K47 2011	Open Access Book	Book	Searching... Unknown

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Summary

As the tools and techniques of structural biophysics assume greater roles in biological research and a range of application areas, learning how proteins behave becomes crucial to understanding their connection to the most basic and important aspects of life.

With more than 350 color images throughout, Introduction to Proteins: Structure, Function, and Motionpresents a unified, in-depth treatment of the relationship between the structure, dynamics, and function of proteins. Taking a structural-biophysical approach, the authors discuss the molecular interactions and thermodynamic changes that transpire in these highly complex molecules.

The text incorporates various biochemical, physical, functional, and medical aspects. It covers different levels of protein structure, current methods for structure determination, energetics of protein structure, protein folding and folded state dynamics, and the functions of intrinsically unstructured proteins. The authors also clarify the structure-function relationship of proteins by presenting the principles of protein action in the form of guidelines.

This comprehensive, color book uses numerous proteins as examples to illustrate the topics and principles and to show how proteins can be analyzed in multiple ways. It refers to many everyday applications of proteins and enzymes in medical disorders, drugs, toxins, chemical warfare, and animal behavior. Downloadable questions for each chapter are available at CRC Press Online.

Author Notes

Amit Kesselis co-founder of Es-is Technologies Ltd., which designs biocatalysts for the pharmaceutical industry. He also teaches protein biochemistry and biophysics at the Tel Aviv-Yaffo Academic College. During his postdoctoral research at Columbia University, Dr. Kessel focused on various physicochemical aspects of protein-protein interactions at the molecular level.

Nir Ben-Talis a professor in the Department of Biochemistry and Molecular Biology at Tel-Aviv University. His research in computational biology has involved predicting the three-dimensional structures of transmembrane proteins and developing the ConSurf web server for the detection of functional regions by mapping evolutionary data on protein structures.