Cover image for Ocular angiogenesis : diseases, mechanisms, and therapeutics
Title:
Ocular angiogenesis : diseases, mechanisms, and therapeutics
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Series:
Opthalmology research
Publication Information:
Totowa, NJ : Humana Press Inc., 2006
ISBN:
9781597450478
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Electronic Access:
Full Text
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EB000323 EB 000323 Electronic Book 1:EBOOK
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Summary

Summary

Leading academic and pharmaceutical researchers and clinicians from many disciplines synthesize and summarize current clinical and basic knowledge concerning abnormal growth of blood vessels in the eye, the cause of major neovascular eye diseases. The authors also identify and assess the most promising approaches with potential for commercial exploitation and discuss the challenges encountered in developing therapeutics for ocular neovascular diseases. Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches.


Table of Contents

Curtis L. Hagedorn and Ron A. AdelmanJian-Xing Ma and Sarah X. ZhangTrevor R. CarmichaelNahoko Ogata and Kanji TakahashiKyoko Ohno-Matsui and Takashi TokoroJonathan Stone and Trent Sandercoe and Jan ProvisJames C. Tsai and M. Bruce ShieldsJyotirmay BiswasNader Sheibani and Daniel M. AlbertJacquie Greenberg and Ari Ziskind and Stephen P. DaigerSam Dahr and Karl G. CsakyAndreas Bikfalvi and Sophie JaverzatOlga V. VolpertBela Anand-ApteMatthew R. Ritter and Martin FriedlanderChi-Chao Chan and Robert B. NussenblattMing Lu|vDonald J. D'AmicoStella M. Robertson and Alberta A. Davis and David C. Dahlin and Abbot F. ClarkBrian J. Raisler and Kenneth I. Berns and William W. HauswirthJohn M. Nickerson and R. Keith Shuler, Jr. and John B. Davies and Phyllis K. Dioguardi and Steven M. Wolchok and Vincent T. Ciavatta and Jeffrey H. Boatright and Henry F. EdelhauserHeather Sheardown and W. Mark Saltzman
Prefacep. v
Contributorsp. xi
Companion CDp. xv
I Angiogenic Diseases
1 Age-Related Macular Degenerationp. 3
2 Endogenous Angiogenic Inhibitors in Diabetic Retinopathyp. 23
3 Corneal Angiogenesisp. 45
4 Polypoidal Choroidal Vasculopathyp. 73
5 Myopic Choroidal Neovascularizationp. 85
6 Mechanisms of the Formation and Stability of Retinal Blood Vesselsp. 101
7 Neovascular Glaucomap. 127
8 Eales' Diseasep. 149
9 Angiogenesis and Ocular Tumorigenesisp. 161
10 Genetics of Ocular Vascular Diseasep. 173
II Endogenous Promoters And Inhibitors Of Angiogenesis
11 Vascular Endothelial Growth Factor and Retinal Diseasesp. 191
12 The Role of Fibroblast Growth Factors in Ocular Angiogenesisp. 205
13 Control of Neovascularization and Cell Survival in the Eye by PEDFJoyce Tombran-Tink and Colin J. Barnstable
14 Thrombospondin: Guarding the Clear Viewp. 233Arin Auro
15 Regulation of Ocular Angiogenesis by Matrix Proteases and Tissue Inhibitors of Metalloproteinasesp. 257
16 Integrins in Ocular Angiogenesisp. 279
17 Ocular Inflammation and Neovascularizationp. 291
III Therapeutics And Delivery For Angiogenic Eye Diseases
18 Anti-VEGF Therapies for Diseases of the Retina and Choroidp. 309
19 Anecortave Acetate: A Novel Ocular Angiostatic Agentp. 341
20 Gene Therapy for Neovascular Retinopathiesp. 355
21 Noninvasive Delivery of DNA Into the Eyep. 373
22 Novel Drug Delivery Systems for Posterior Segment Ocular Diseasep. 393
Indexp. 409