Cover image for Acute promyelocytic leukemia : molecular genetics, mouse models and targeted therapy
Title:
Acute promyelocytic leukemia : molecular genetics, mouse models and targeted therapy
Series:
Current Topics in Microbiology and Immunology 313
Publication Information:
Berlin ; New York : Springer-Verlag, 2007
Physical Description:
vi, 273 p. : ill., digital ; 24 cm.
ISBN:
9783540345947

9783540345923
General Note:
Available online version
Added Corporate Author:
Electronic Access:
Online via Springer eBook

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Summary

Summary

Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development of targeted therapy.