Title:
Signaling by toll-like receptors
Series:
Methods in signal transduction series
Methods in signal transduction.
Publication Information:
Boca Raton, FL : CRC Press, 2008.
Physical Description:
xxi, 195 p., [2] p. of plates : ill. (some col.) ; 25 cm.
ISBN:
9781420043181
Added Author:
Electronic Access:
Table of contents only http://www.loc.gov/catdir/toc/ecip0814/2008012853.htmlAvailable:*
Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
---|---|---|---|---|---|
Searching... | 30000010251148 | QP517.C45 S557 2008 | Open Access Book | Book | Searching... |
On Order
Summary
Summary
The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors.
Author Notes
Gregory W. Konat
Table of Contents
Series Preface | p. vii |
Preface | p. ix |
About the Editor | p. xi |
Contributors | p. xiii |
Abbreviations | p. xv |
List of Protocols | p. xix |
Chapter 1 Assessing the Response of Cells to TLR Stimulation | p. 1 |
Chapter 2 TLR Ligands in Experimental Settings Their Purity and Specificity | p. 23 |
Chapter 3 Analysis of TLR Expression, Regulation, and Signaling | p. 39 |
Chapter 4 Intracellular Trafficking of Toll-Like Receptors | p. 59 |
Chapter 5 The Role of Small RhoGTPases in TLR Signaling | p. 73 |
Chapter 6 Use of Engineered [beta]-Lactamase Fragment Complementation to Detect the Associations of Toll-Like Receptors and Signaling Adaptors | p. 87 |
Chapter 7 Use of Toll-Like Receptor Chimeras to Dissect Mechanisms of Receptor Localization and Signaling | p. 109 |
Chapter 8 Engagement of Toll-Like Receptors Modulates Chemokine Receptor Signaling | p. 131 |
Chapter 9 Role of Toll-Like Receptor Signaling in Central Nervous System Infections | p. 145 |
Chapter 10 The Influence of Injury on Toll-Like Receptor Responses | p. 163 |
Index | p. 181 |