Cover image for Signaling by toll-like receptors
Title:
Signaling by toll-like receptors
Series:
Methods in signal transduction series

Methods in signal transduction.
Publication Information:
Boca Raton, FL : CRC Press, 2008.
Physical Description:
xxi, 195 p., [2] p. of plates : ill. (some col.) ; 25 cm.
ISBN:
9781420043181
Added Author:
Electronic Access:
Table of contents only http://www.loc.gov/catdir/toc/ecip0814/2008012853.html

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30000010251148 QP517.C45 S557 2008 Open Access Book Book
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Summary

Summary

The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors.


Author Notes

Gregory W. Konat


Table of Contents

Kiyoshi Takeda and Masahiro Yamamoto and Kenya HondaMin-Fu TsanHui Xiao and Xiaoxia Li and Derek W. AbbottHarald Husebye and Oyvind Halaas and Harald Stenmark and Terje EspevikMonica Ruse and Ulla G. KnausHyun-Ku Lee and Peter S. TobiasTadashi Nishiya and Anthony L. DeFrancoChong-Shan Shi and John H. KehrlTammy KielianThomas J. Murphy and Adrian A. Maung and Hugh M. Paterson and James A. Lederer
Series Prefacep. vii
Prefacep. ix
About the Editorp. xi
Contributorsp. xiii
Abbreviationsp. xv
List of Protocolsp. xix
Chapter 1 Assessing the Response of Cells to TLR Stimulationp. 1
Chapter 2 TLR Ligands in Experimental Settings Their Purity and Specificityp. 23
Chapter 3 Analysis of TLR Expression, Regulation, and Signalingp. 39
Chapter 4 Intracellular Trafficking of Toll-Like Receptorsp. 59
Chapter 5 The Role of Small RhoGTPases in TLR Signalingp. 73
Chapter 6 Use of Engineered [beta]-Lactamase Fragment Complementation to Detect the Associations of Toll-Like Receptors and Signaling Adaptorsp. 87
Chapter 7 Use of Toll-Like Receptor Chimeras to Dissect Mechanisms of Receptor Localization and Signalingp. 109
Chapter 8 Engagement of Toll-Like Receptors Modulates Chemokine Receptor Signalingp. 131
Chapter 9 Role of Toll-Like Receptor Signaling in Central Nervous System Infectionsp. 145
Chapter 10 The Influence of Injury on Toll-Like Receptor Responsesp. 163
Indexp. 181