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Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
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Searching... | 32050000000340 | QH588.S83 S74 2013 | Open Access Book | Book | Searching... |
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Summary
Summary
While the potential of stem cells is recognized, their proliferation and differentiation must be more precisely controlled to maximize the production of therapeutically relevant cells and for cell replacement therapies to minimize contamination with residual cells that can give rise to side effects. How can engineers make contributions to address these challenges? With contributions from pioneers and experts, Stem Cell Engineering: Principles and Practices highlights recent advances in the understanding of the cellular and molecular composition of the stem cell niche, as well as approaches to build upon this basic information to direct stem cell differentiation into therapeutically valuable lineages.
The growing recognition of stem cells as an important and exciting field will continue to draw investigators with diverse backgrounds--from biology, engineering, and the physical sciences--and thereby enable further progress in these and other new directions. This book discusses advances made during the last decade that have led to increasingly defined culture systems for growing stem cells, starting from co-culture with feeder cells in the presence of serum to growth on synthetic substrates in defined medium. In addition to highlighting many recent advances, it underscores the need for future work.
Author Notes
David Schaffer, Joseph d. Bronzino, Donald R. Peterson
Table of Contents
Introduction | p. vii |
Editors | p. xi |
Contributors | p. xiii |
1 Engineering the Pluripotent Stem Cell Niche for Directed Mesoderm DifferentiationCéline L. Bauwens and Kelly A. Purpura and Peter W. Zandstra | |
2 Cell Mechanobiology in Regenerative Medicine: Lessons from CancerBadriprasad Ananthanarayanan and Sanjay Kumar | |
3 Systems-Engineering Principles in Signal Transduction and Cell-Fate ChoiceKarin J. Jensen and Anjun K. Bose and Kevin A. Janes | |
4 Biomaterial Scaffolds for Human Embryonic Stem Cell Culture and DifferentiationStephanie Willerth and David Schaffer | |
5 Stem Cells and Regenerative Medicine in the Nervous SystemShelly Sakiyama-Elbert | |
6 Stem Cells and Regenerative Medicine for Treating Damaged MyocardiumRohini Gupta and Kunal Mehtani and Kimberly R. Kam and Kevin E. Healy | |
7 Stem Cells and HematopoiesisKrista M. Fridley and Krishnendu Roy | |
8 Synthetic Biomaterials and Stem Cells for Connective Tissue EngineeringAmeya Phadke and Shyni Varghese | |
9 Derivation and Expansion of Human Pluripotent Stem CellsSean P. Palecek | |
10 Bioreactors for Stem Cell Expansion and DifferentiationCarlos A. V. Rodrigues and Tiago G. Fernandes and Maria Margarida Diogo and Cláudia Lobato da Silva and Joaquim M. S. Cabral | |
Index |