Cover image for Chromatography of pharmaceuticals : natural, synthetic, and recombinant products
Title:
Chromatography of pharmaceuticals : natural, synthetic, and recombinant products
Series:
ACS symposium series ; 512
Publication Information:
Washington, D.C. : American Chemical Society, 1992
ISBN:
9780841224988
General Note:
Developed from a symposium sponsored by the Division of Agricultural and Food Chemistry of the American Chemical Society at the Fourth Chemical Congress of North America (202nd National Meeting of the American Chemical Society), New York, New York, August 25-30, 1991
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30000002562191 RS189.5.C48 C47 1992 Open Access Book Proceedings, Conference, Workshop etc.
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30000002619868 RS189.5.C48 C47 1992 Open Access Book Proceedings, Conference, Workshop etc.
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Summary

Summary

Describes the role of chromatography in the development of new drugs. Features chapters on the analysis of natural and recombinant pharmaceutical products. Covers new techniques such as capillary electrophoresis and a number of hyphenated techniques that combine liquid chromatography or gas chromatography with mass spectrometry. Describes such applications as impurity analysis, chiral separations, metabolic studies, robotics, and support of biotechnology products. Also describes trace and ultratrace analyses in a variety of matrices.


Author Notes

Satinder Ahuja is at CIBA-GEIGY Corporation.


Table of Contents

Chromatography and Pharmaceutical Analysis
Chromatography and New Drug Development
Alternate Strategies for Analysis of Pharmaceuticals
Ruggedness of Impurity Determinations in Pharmaceuticals
High-Performance Liquid Chromatography
Analysis with Ultraviolet Detection
High-Performance Liquid Chromatography in Pharmaceutical
Development of Antibiotic Products
Gas Chromatography and Pharmaceutical Analyses
Gas Chromatography and Mass Spectrometry of Erythrina
Alkaloids from the Foliage of Genetic Clones of Three Erythrina Species
Developing Stereoselective High-Performance Liquid Chromatographic
Assays for Pharmacokinetic Studies
Direct Enantiomeric Separation and Analysis of Some Aromatase
Inhibitors on Cellulose-Based Chiral Stationary Phases
Chromatographic Analysis of Host-Cell Protein Impurities in Pharmaceuticals Derived from Recombinant DNA
Binding Proteins in Development of Online
Postcolumn Reaction Detection Systems for Liquid Chromatography
Determination of a New Oral Cephalosporin in Biological Fluids
Liquid Chromatographic, Ultraviolet, and Mass Spectrometric Methods
Drugs and Metabolites in Biological Fluids
Automated Analysis by Laboratory Robotics
Preparative Separations of Glycerophospholipids by High-Performance Liquid Chromatography
Small-Molecule Pharmaceutical Separations by Capillary Electrophoresis: Method Development and Manipulation of Selectivity